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|---|---|---|---|
| 001 | EBC144652 | ||
| 003 | MiAaPQ | ||
| 005 | 20181121123434.0 | ||
| 006 | m o d | | ||
| 007 | cr cnu|||||||| | ||
| 008 | 181113s1999 xx o ||||0 eng d | ||
| 020 |
_a9780511149047 _q(electronic bk.) |
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| 020 | _z9780521641012 | ||
| 035 | _a(MiAaPQ)EBC144652 | ||
| 035 | _a(Au-PeEL)EBL144652 | ||
| 035 | _a(CaPaEBR)ebr10064630 | ||
| 035 | _a(CaONFJC)MIL15359 | ||
| 035 | _a(OCoLC)437072463 | ||
| 040 |
_aMiAaPQ _beng _erda _epn _cMiAaPQ _dMiAaPQ |
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| 050 | 4 | _aRC641.7.A6 A656 2000 | |
| 082 | 0 | _a616.152 | |
| 100 | 1 | _aSchrezenmeier, Hubert. | |
| 245 | 1 | 0 |
_aAplastic Anemia : _bPathophysiology and Treatment. |
| 264 | 1 |
_aCambridge : _bCambridge University Press, _c1999. |
|
| 264 | 4 | _c©1999. | |
| 300 | _a1 online resource (406 pages) | ||
| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 505 | 0 | _aCover -- Half-title -- Title -- Copyright -- Contents -- Contributors -- Preface -- Part I Pathophysiology of acquired aplastic anemia -- 1 Stem cell defect in aplastic anemia -- Abbreviations -- Normal stem cells -- Definition -- Regulation -- The experimental study of primitive hemopoietic cells -- Selection of primitive cells by phenotype -- How many stem cells get to express themselves? -- Aplastic anemia stem cells -- Functional assessment of AA hemopoietic progenitor cells -- Phenotypic quantitation of AA hemopoietic (CD34+) cells -- Assessment of the long-term marrow-repopulating ability of AA hemopoietic cells -- Mobilizing potential of AA progenitor cells -- Apoptotic properties of AA CD34+ cells -- Analysis of telomeric DNA length in AA -- Conclusion -- References -- 2 Cytokine abnormalities in aplastic anemia -- Introduction -- Erythropoietin (EPO) -- Granulocyte colony-stimulating factor (G-CSF) -- Thrombopoietin (TPO) -- Stem cell factor (SCF) -- Granulocyte-macrophage colony-stimulating factor (GM-CSF) -- Flt-3 ligand (Flt-3L) -- Interleukin-1 (IL-1) -- Production of cytokines by marrow stromal cells -- Rationale for the therapeutic use of cytokines -- Conclusion -- References -- 3 Role of T-lymphocytes in the pathophysiology of aplastic anemia -- Introduction -- Immunophenotyping data on T-cells and natural killer cells in bone marrow and peripheral blood -- CD4 and CD8 T-cells -- Activated T-cell subpopulation -- T-cell receptor VBeta subfamily -- Natural killer cells -- Markers of T-cell activation -- Activation antigens -- Cytokine production -- Stress proteins -- Production of myelosuppressive cytokines by T-lymphocytes -- Reactivity of T-lymphocytes against hemopoietic progenitor cells -- Evidence of the involvement of an antigen-driven response in the development of AA. | |
| 505 | 8 | _aHemopoietic progenitor cells as a target of T-cell attack -- Association of certain HLA alleles with a susceptibility to AA -- Clonal predominance in T-cell subsets defined by T-cell receptor VBeta expression -- Establishment of a T-cell clone reactive to hemopoietic cells from AA patients -- Conclusion -- References -- 4 Role of apoptosis in the pathophysiology of aplastic anemia -- Introduction -- Features of apoptotic cells -- Control of apoptosis -- Apoptosis: role in immune regulation -- Methods of detecting apoptotic cells -- Apoptosis in progenitor cells in the bone marrow of those with aplastic anemia -- Expression of Fas on normal hemopoietic progenitor cells -- Expression of Fas on progenitor cells in aplastic anemia -- Modulation of apoptosis by therapeutic intervention -- Conclusion -- References -- 5 The interrelation between aplastic anemia and paroxysmal nocturnal hemoglobinuria -- Introduction -- AA-PNH syndrome - clinical observations -- The deficiency of GPI-anchored proteins in AA-PNH syndrome -- The GPI anchor and its biosynthesis (reviewed in Rosse, 1997 -- Socié, 1997) -- The most widely studied GPI-anchored proteins (reviewed in Rosse, 1997 -- Socié, 1997) -- The GPI-anchored protein deficiency (reviewed in Rosse, 1997 -- Socié, 1997) -- The GPI-anchored protein deficiency in AA-PNH syndrome -- Mutations of the PIG-A gene in AA-PNH syndrome -- Molecular biology of the PIG-A gene -- Abnormalities of the PIG-A gene in PNH -- Abnormalities of the PIG-A gene in AA-PNH syndrome -- Conclusion: the mutations of the PIG-A gene as a common genetic basis for PNH and AA-PNH syndrome -- References -- 6 Aplastic anemia and other clonal disorders -- Introduction -- Clinical observations: the evolution of AA to myelodysplastic syndrome and acute myelogenous leukemia. | |
| 505 | 8 | _aStudies on clonal hemopoiesis in AA patients using X-linked DNA polymorphisms -- Cytogenetic abnormalities in patients with severe aplastic anemia -- Conclusion -- References -- Part II Epidemiology and clinical features of acquired aplastic anemia -- 7 Epidemiology and etiology of aplastic anemia -- Introduction -- The role of medical drugs: a good old theory revisited -- Environmental and industrial chemicals -- Viruses -- Risk factors others than exposure -- Conclusion -- References -- 8 Clinical presentation, natural course, and prognostic factors -- Clinical manifestations -- Complementary investigations -- Peripheral blood cell counts -- Other analytical data -- The cytology and histopathology of medullary aplasia -- Isotopic investigations of hemopoiesis -- Proton magnetic resonance imaging and spectroscopy -- Follow-up and survival -- Prognosis identification -- The prognostic value of symptoms -- The prognostic value of peripheral blood cell counts -- The prognostic value of the cytology and histopathology of medullary aplasia -- The prognostic value of isotope examinations -- Statistical prediction models -- International criteria -- Conclusion -- References -- Part III Treatment of acquired aplastic anemia -- 9 Supportive treatment of patients with severe aplastic anemia -- Introduction -- Prevention and treatment of infections -- Risk of infections -- Types of infections in SAA patients -- Prevention of infections -- Antibacterial chemoprophylaxis -- Antiviral prophylaxis -- Diagnosis of infection -- Investigation of fever -- Investigation of patients with pulmonary infiltrates -- Treatment of infection -- Treatment of bacterial infections -- Treatment of fungal infections -- Treatment of viral infections -- Transfusion support -- Transfusions and risk for graft rejection after BMT -- Alloimmunization after transfusion. | |
| 505 | 8 | _aTransmission of infectious agents -- Transfusion-associated GVHD -- Iron overload -- Conclusion -- References -- 10 Immunosuppressive treatment of aplastic anemia -- Introduction -- Lessons from the clinical trials -- Effectiveness of ALG -- The impact of severity of disease -- Cyclosporin -- Intensification of immunosuppression -- Adjuncts to immunosuppression -- Splenectomy -- Timing and quality of response -- Mechanism of action of ALG and cyclosporin -- Treatment schedules -- Adverse events of ALG -- Immunosuppression in elderly patients -- Relapses and nonresponses -- New approaches to immunosuppressive treatment -- Conclusion -- Acknowledgements -- References -- 11 Role of cytokines in the treatment of aplastic anemia -- The rationale and potential aims of growth factor treatment in aplastic anemia -- Serum/plasma levels and production of endogenous growth factors in aplastic anemia -- Clinical trials of hemopoietic growth factors in aplastic anemia -- Granulocyte colony-stimulating factor -- Granulocyte/macrophage colony-stimulating factor (GM-CSF) -- Erythropoietin -- Interleukin-3 (IL-3) -- Interleukin-1 (IL-1) -- Interleukin-6 (IL-6) -- Stem-cell factor (SCF) -- Conclusion -- References -- 12 HLA-identical sibling bone marrow transplantation to treat severe aplastic anemia -- Introduction -- HLA-identical sibling transplants -- Survival, current results, and trends over time -- Engraftment -- Hemopoietic chimerism -- Acute GVHD -- Chronic GVHD -- Interstitial pneumonitis -- Late complications -- The influence of SAA etiology on outcome -- Syngeneic transplants -- HLA-phenotypically identical donors -- Conclusion -- References -- 13 Alternative donor bone marrow transplantation for severe acquired aplastic anemia -- Introduction -- Prognostic factors for HLA-identical sibling BMT -- Partially matched family donor BMT: early experience. | |
| 505 | 8 | _aHLA-matched unrelated donor BMT: early experience -- Analysis of factors affecting outcome of alternative donor BMT -- Patients and methods -- Patient population -- Donor population and HLA matching -- Transplant data -- Outcomes analyzed -- Statistical methods -- Results -- Survival -- Engraftment -- Acute GVHD -- Chronic GVHD -- Cause of death -- Discussion -- Future directions -- Transfusion policy in patients with SAA -- HLA molecular epitope analysis -- Conclusion -- References -- 14 Treatment of children with acquired aplastic anemia -- Introduction -- BMT from HLA-identical siblings -- BMT from alternative donors -- Immunosuppressive treatment -- Hemopoietic growth factors -- Late effects on children -- Treatment results obtained in the last 5 years in Europe -- Conclusion -- References -- 15 Long-term follow-up of patients with aplastic anemia: clonal malignant and nonmalignant complications -- Introduction -- Historical background -- Secondary MDS or leukemia -- New solid cancers -- Paroxysmal nocturnal hemoglobinuria -- Conclusion -- References -- 16 Guidelines for treating aplastic anemia -- Decision making: immunosuppressive treatment versus allogeneic bone marrow transplantation as first-line treatment of… -- Bone marrow transplantation -- HLA-matched sibling transplantation -- Unrelated and family-mismatched donor transplants -- Immunosuppressive treatment -- Failures to respond to first-line treatment/relapse -- Failures to respond to second-line treatment -- Age limit for immunosuppressive treatment -- Myelodysplastic syndrome/leukemia after treatment -- Conclusion -- Part IV Fanconi's anemia -- 17 Clinical features and diagnosis of Fanconi's anemia -- Clinical suspicion of Fanconi's anemia -- Diagnosis of FA -- Hematological manifestations -- Leukemia -- Myelodysplastic syndrome -- Cancer -- Liver disease -- Reproduction -- Prognosis. | |
| 505 | 8 | _aConclusion. | |
| 520 | _aComprehensive and up-to-date clinical reference, with an emphasis on treatment. | ||
| 588 | _aDescription based on publisher supplied metadata and other sources. | ||
| 590 | _aElectronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2018. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries. | ||
| 650 | 0 | _aAnemia, Aplastic--physiopathology. | |
| 655 | 4 | _aElectronic books. | |
| 700 | 1 | _aBacigalupo, Andrea. | |
| 776 | 0 | 8 |
_iPrint version: _aSchrezenmeier, Hubert _tAplastic Anemia : Pathophysiology and Treatment _dCambridge : Cambridge University Press,c1999 _z9780521641012 |
| 797 | 2 | _aProQuest (Firm) | |
| 856 | 4 | 0 |
_uhttps://ebookcentral.proquest.com/lib/buse-ebooks/detail.action?docID=144652 _zClick to View |
| 999 |
_c33218 _d33218 |
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