Front Cover -- The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents -- Copyright Page -- Contents -- Preface -- List of Contributors -- List of Reviewers -- I. GENERAL -- 1. Ethical Considerations and Regulatory Issues -- Introduction -- Ethical Concepts -- Moral Theories -- Descriptive Laboratory Animal Use Ethics -- Ethical Principles -- Respect for Life -- Societal Benefit -- Non-Maleficence -- The Three Rs (Replacement, Reduction, and Refinement) -- Replacement -- Reduction -- Refinement -- Ethical Challenges -- Breeding Colonies -- Genetically Modified Rodents -- Cancer Research -- Perinatal Animal Use -- Neuroscience and Behavioral Research -- Food and Fluid Restriction -- Neuroanatomic Studies -- Neural Injury and Disease -- Behavioral Studies -- Prolonged Restraint and Anesthesia -- Restraint of Awake Animals -- Prolonged Studies in Anesthetized Animals -- Institutional Animal Welfare Oversight -- Regulations and Non-regulatory Considerations -- United States Regulatory Considerations -- United States Animal Welfare Act -- Public Health Service Policy on Humane Care and Use of Animals -- Food and Drug Administration Good Laboratory Practices -- Interagency Cooperation -- Environmental Protection Agency Good Laboratory Practices -- Non-Regulatory Considerations -- Institute for Laboratory Animal Research -- Guide for the Care and Use of Laboratory Animals (Guide) -- International Regulations, Policies, and Standards -- AAALAC, International -- Canada -- European Union -- Pacific Rim -- Australia -- New Zealand -- Japan -- South Korea -- Philippines -- Thailand -- China -- Taiwan -- Singapore -- Hong Kong -- Conclusion -- References -- 2. Anesthesia and Analgesia -- Pre-anesthetic Preparation -- Physical Examination -- Fasting -- Stabilization -- Regulatory Requirements -- Controlled Substances -- Pharmacology -- Anticholinergics.

Phenothiazines -- Benzodiazepines -- Alpha2-Agonists -- Systemic Analgesics -- Opioids -- Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) -- Tramadol -- Gabapentin -- Amantadine -- Local Anesthetics -- Glucocorticoids -- N-Methyl-D-Aspartic Acid (NMDA) Antagonist -- Ketamine -- Tiletamine-Zolazepam -- Propofol -- Barbiturates -- Inhalation Anesthetics -- Anesthesia Circuits -- Induction Chambers -- Breathing Circuits -- Vaporizer Types and Machines -- Ventilators -- Regulatory Monitoring Requirements -- Anesthesia Waste Gas Scavenging -- Anesthesia Monitoring and Support -- Anesthetic Depth -- Respiratory Function -- Cardiovascular Function -- Temperature -- Fluid Therapy -- Intubation -- Surgical Anesthesia -- Post-operative Monitoring and Pain Assessment -- Pain Assessment -- Post-Operative Analgesia -- Post-Operative Monitoring -- References -- 3. Clinical Biochemistry and Hematology -- Introduction -- Clinical Biochemistry -- Introduction -- Sample Collection -- Restraint -- Blood Collection -- Urine Collection -- Carbohydrate Metabolism -- Glucose -- Lipid Metabolism -- Cholesterol -- Triglycerides -- Enzymes -- Alkaline Phosphatase (ALP) -- Alanine Aminotransferase (ALT) -- Aspartate Aminotransferase (AST) -- Lactate Dehydrogenase (LDH) -- Creatine Kinase (CK) -- Sorbitol Dehydrogenase (SDH) -- Amylase -- Glutamate Dehydrogenase (GDH) -- Hormones -- Adrenal Hormones -- Thyroid Hormones -- Reproductive Hormones -- Liver Function -- Enzymes -- Total Bilirubin -- Bile Acids -- Serum Proteins -- Kidney Function -- Blood Urea Nitrogen (BUN) -- Creatinine -- Electrolytes -- Bicarbonate (HCO-3) -- Calcium (Ca) -- Chloride (Cl-) -- Magnesium (Mg2+) -- Phosphorus (P) -- Potassium (K+) -- Sodium (Na+) -- Rabbit -- Sample Collection -- Restraint -- Blood -- Urine -- Reference Values and Sources of Variation -- Blood -- Urine -- Carbohydrate Metabolism.

Lipid Metabolism -- Enzymes -- Hormones -- Liver Function -- Kidney Function -- Electrolytes -- Guinea Pig -- Sample Collection -- Restraint -- Blood -- Urine -- Reference Values and Sources of Variation -- Blood -- Urine -- Carbohydrate Metabolism -- Lipid Metabolism -- Enzymes -- Hormones -- Liver Function -- Kidney Function -- Electrolytes -- Hamster -- Sample Collection -- Restraint -- Blood -- Urine -- Reference Values and Sources of Variation -- Blood -- Urine -- Carbohydrate Metabolism -- Lipid Metabolism -- Enzymes -- Hormones -- Liver Function -- Kidney Function -- Electrolytes -- Other Rodents -- Gerbil -- Sample Collection -- Reference Values and Sources of Variation -- Chinchilla -- Sample Collection -- Reference Values and Sources of Variation -- Degu -- Sample Collection -- Reference Values and Sources of Variation -- Deer Mouse -- Sample Collection -- Reference Values and Sources of Variation -- Dormouse -- Sample Collection -- Reference Values and Sources of Variation -- Kangaroo Rat -- Sample Collection -- Reference Values and Sources of Variation -- Cotton Rat -- Sample Collection -- Reference Values and Sources of Variation -- Sand Rat -- Sample Collection -- Reference Values and Sources of Variation -- Hematology -- Introduction -- Blood Collection and Sample Preparation -- Blood Collection -- Sample Preparation -- Blood Volume -- Total Blood Volume -- Plasma Volume -- Peripheral Blood Cells -- Erythrocytes -- Leukocytes -- Platelets (Thrombocytes) -- Coagulation -- Bleeding Time (BT) -- Prothrombin Time (PT) -- Activated Partial Thromboplastin Time (APTT) -- Thrombin Time (TT) -- Fibrinogen Concentration -- Bone Marrow -- Rabbit -- Sample Collection -- Blood -- Bone Marrow -- Reference Values and Unique Characteristics -- Blood Volume -- Peripheral Blood Cells -- Coagulation -- Bone Marrow -- Guinea Pig -- Sample Collection.

Blood -- Bone Marrow -- Reference Values and Unique Characteristics -- Blood Volume -- Peripheral Blood Cells -- Bone Marrow -- Hamster -- Sample Collection -- Blood -- Reference Values and Unique Characteristics -- Blood Volume -- Peripheral Blood Cells -- Coagulation -- Bone Marrow -- Other Rodents -- Gerbil -- Sample Collection -- Reference Values and Unique Characteristics -- Chinchilla -- Sample Collection -- Reference Values and Unique Characteristics -- Degu -- Deer Mouse -- Sample Collection -- Reference Values and Unique Characteristics -- Dormouse -- Kangaroo Rat -- Sample Collection -- Reference Values and Unique Characteristics -- Cotton Rat -- Sample Collection -- Reference Values and Unique Characterstics -- Sand Rat -- Sample Collection -- Reference Values and Unique Characteristics -- References -- 4. Euthanasia and Necropsy -- Introduction -- Euthanasia -- Introduction and Background -- Chemical Methods -- Inhalants -- Carbon Dioxide -- Carbon Monoxide -- Inhalant Anesthetics -- Inert Gases -- Injectable Agents -- Barbiturates -- Potassium Chloride -- Unacceptable Injectable Agents -- Physical Methods -- Cervical Dislocation -- Captive Bolt -- Decapitation -- Microwave Irradiation -- Euthanasia of the Rabbit -- Euthanasia of the Guinea Pig -- Euthanasia of the Hamster -- Euthanasia of Mice, Rats, and Other Rodents -- Necropsy -- General Considerations -- Preparation for Necropsy -- Necropsy Procedure -- Collection of Blood and Urine Samples -- Exsanguination and Euthanasia -- External Examination -- Dissection, Gross Examination, and Collection of Tissue Samples -- Sectioning of Skin and Examination of Subcutaneous Tissues -- Opening the Abdominal Cavity -- Urogenital Organs -- Spleen, Mesenteric Lymph Nodes, Pancreas, and Digestive Tract -- Liver, GallBladder, Adrenal Glands, and Kidney -- Thoracic Cavity.

Sciatic Nerve, Skeletal Muscle, Bones, and Joints -- Eyes, Brain, and Spinal Cord -- Skin -- Pathology Considerations -- Descriptive Pathology -- Tissues Sampling, Fixation, and Trimming -- References -- 5. Zoonoses and Occupational Health -- Introduction -- Viral Diseases -- Hantavirus -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Lassa Virus -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Lymphocytic Choriomeningitis Virus -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Rabies Virus -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Rickettsial Diseases -- Coxiella burnetii -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Rickettsia akari -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Rickettsia rickettsii -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Chlamydial Diseases -- Chlamydophyila caviae -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Chlamydophyila psittaci -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Bacterial Diseases -- Bordetella bronchiseptica -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Borrelia burgdorferi (Lyme's Disease) -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Francisella tularensis (Tularemia) -- Reservoir and Incidence -- Mode of Transmission -- Clinical Signs -- Diagnosis and Prevention -- Leptospira spp. -- Reservoir and Incidence.

Mode of Transmission.

The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents is a single volume, comprehensive book sanctioned by the American College of Laboratory Animal Medicine (ACLAM), covering the rabbit, guinea pig, hamster, gerbil and other rodents often used in research. This well-illustrated reference won a 2012 PROSE Award for Best Single Volume Reference in Science from the Association of American Publishers. The book includes basic biology, anatomy, physiology, behavior, infectious and noninfectious diseases, husbandry and breeding, common experimental methods, and use of the species as a research model. With many expert contributors, this will be an extremely valuable publication for biomedical researchers, laboratory animal veterinarians and other professionals engaged in laboratory animal science. 2012 PROSE Award winner for Best Single Volume Reference in Science from the Association of American Publishers One-stop resource for advancements in the humane and responsible care of: rabbit, guinea pig, hamster, gerbil, chinchilla, deer mouse, kangaroo rat, cotton rat, sand rat, and degu Includes up-to-date, common experimental methods Organized by species for easy access during bench research.

Description based on publisher supplied metadata and other sources.

Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2018. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.