Trafficking is an emerging concern in West Africa. In 2011, 17 percent of all cocaine consumed in Europe-21 tons-passed through the region, for a retail value of US .7 billion. This paper discusses the evolution of trafficking in the region and provides estimates of the size and value of trafficking flows to demonstrate the significance of this illegal activity. Although this topic is gaining increasing attention, less attention has been has been paid to how trafficking is perpetuating fragility. This paper contributes to this area of research by identifying five channels through which trafficking is intensifying fragility in the region. The relative importance of each channel is discussed, with specific countries as case-study examples. Possible programmatic responses are then suggested with examples of policy approaches successfully adopted elsewhere in the world.